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Funding This work was supported by the NWO (Dutch Research Council) Veni Fellowship [grant number 09150161810102]

Nicotine and alcohol elevate your blood pressure, constricting your blood vessels, which absorbing and using essential nutrient much more difficult harder

It slows and impairs cognition and reaction time and the cognitive skills, impairs judgement, interferes with motor function resulting in motor incoordination, loss of balance, confusion, sedation, numbness and slurred speech, impairs memory formation, and causes sensory impairment

Currently, he has severe persisting neuropathy despite intramuscular injection of hydroxocobalamin on alternating days, and the use of pregabalin, amitriptyline and a morphine preparation

J Surg Oncol 122(3):515-522, 2020

So how do you approach the conversation